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Stephen F Vatner Selected Research

adenylyl cyclase type V

1/2018A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion.
7/2015Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
2/2014'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption'.
7/2013Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.
9/2010Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.

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Stephen F Vatner Research Topics

Disease

19Heart Failure
01/2018 - 08/2003
16Cardiomyopathies (Cardiomyopathy)
12/2020 - 02/2002
14Hypertrophy
01/2019 - 02/2002
10Cardiomegaly (Heart Hypertrophy)
01/2011 - 07/2002
8Infarction (Infarctions)
01/2020 - 10/2003
6Myocardial Ischemia (Ischemic Heart Diseases)
02/2015 - 02/2002
6Ischemia
04/2011 - 11/2002
5Fibrosis (Cirrhosis)
01/2020 - 02/2002
5Myocardial Infarction
01/2018 - 02/2006
4Obesity
12/2020 - 03/2012
4Neoplasms (Cancer)
12/2020 - 09/2011
4Hypertension (High Blood Pressure)
04/2016 - 10/2011
3Hypoxia (Hypoxemia)
01/2012 - 02/2006
2Atherosclerosis
11/2013 - 06/2003
2Pathologic Constriction (Stenosis)
12/2011 - 01/2002
2Systolic Heart Failure
03/2011 - 07/2010
2Body Weight (Weight, Body)
11/2009 - 07/2002
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
11/2009 - 10/2006
2Bradycardia
02/2007 - 08/2003
2Burns
02/2006 - 11/2003
2Myocardial Stunning (Stunned Myocardium)
10/2003 - 11/2002
1Metabolic Diseases (Metabolic Disease)
12/2020
1Osteoporosis
12/2020
1Fatigue
01/2019
1Coronary Artery Disease (Coronary Atherosclerosis)
01/2018
1Cardiac Arrhythmias (Arrythmia)
01/2018
1Insulin Resistance
07/2015
1Necrosis
03/2015
1Cicatrix (Scar)
02/2015
1Melanoma (Melanoma, Malignant)
02/2014
1Acute-Phase Reaction
09/2013
1Heart Diseases (Heart Disease)
07/2013
1Coronary Stenosis (Coronary Artery Stenosis)
02/2013

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
09/2013 - 11/2002
9Phosphotransferases (Kinase)IBA
01/2019 - 11/2002
7beta Adrenergic ReceptorsIBA
01/2018 - 12/2003
6CollagenIBA
02/2015 - 12/2003
5adenylyl cyclase type VIBA
01/2018 - 09/2010
5Glucose (Dextrose)FDA LinkGeneric
07/2015 - 01/2002
4Adrenergic Agents (Adrenergic Drugs)IBA
12/2020 - 12/2003
4AntioxidantsIBA
01/2018 - 10/2003
4Adenylyl Cyclases (Adenylyl Cyclase)IBA
11/2014 - 08/2003
4Sirtuin 1IBA
07/2013 - 05/2007
4Atrial Natriuretic Factor (ANF)IBA
11/2009 - 07/2002
3Pharmaceutical PreparationsIBA
01/2018 - 10/2011
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
05/2016 - 04/2013
3Phenylephrine (Neo-Synephrine)FDA LinkGeneric
04/2016 - 08/2003
3Isoproterenol (Isoprenaline)FDA LinkGeneric
03/2015 - 06/2012
3CatecholaminesIBA
07/2013 - 10/2007
3Protein Isoforms (Isoforms)IBA
11/2009 - 02/2006
3salicylhydroxamic acid (SHAM)IBA
10/2008 - 11/2003
2GTP-Binding Proteins (G-Protein)IBA
01/2018 - 09/2010
2CytokinesIBA
02/2015 - 07/2002
2Superoxide DismutaseIBA
11/2014 - 04/2013
2Vidarabine (Vira-A)FDA Link
02/2014 - 06/2012
2Antiviral Agents (Antivirals)IBA
02/2014 - 06/2012
2AdenineFDA LinkGeneric
02/2014 - 06/2012
2Cytoskeletal ProteinsIBA
12/2013 - 08/2008
2Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
09/2013 - 12/2003
2Fatty Acids (Saturated Fatty Acids)IBA
03/2012 - 01/2002
2Myosins (Myosin)IBA
01/2012 - 10/2011
2Adenosine Triphosphate (ATP)IBA
12/2011 - 04/2010
2Calcium Channel Blockers (Blockers, Calcium Channel)IBA
10/2011 - 02/2009
2Cardiac MyosinsIBA
03/2011 - 07/2010
2Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2010 - 10/2003
2CalcineurinIBA
11/2009 - 09/2003
2Angiotensin IIIBA
02/2009 - 06/2003
2Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
02/2009 - 06/2003
2Proteasome Endopeptidase Complex (Proteasome)IBA
10/2008 - 10/2006
2DNA (Deoxyribonucleic Acid)IBA
04/2008 - 11/2002
2Oxygen (Dioxygen)IBA
12/2007 - 10/2003
2Nitric Oxide Synthase (NO Synthase)IBA
02/2006 - 10/2003
2Protein Kinases (Protein Kinase)IBA
02/2006 - 06/2005
2CaspasesIBA
06/2005 - 05/2003
2Ventricular MyosinsIBA
12/2003 - 02/2002
2Glycine (Aminoacetic Acid)FDA LinkGeneric
11/2003 - 10/2003
14-(2-aminoethyl)benzenesulfonylfluoride (AEBSF)IBA
01/2020
1Collagen Type I (Type I Collagen)IBA
01/2020
1Collagen Type III (Type III Collagen)IBA
01/2020
1Small Heat-Shock ProteinsIBA
01/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
01/2019
1tempolIBA
01/2019
1Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA
01/2018
1CatalaseIBA
01/2018
1Adenosine (Adenocard)FDA LinkGeneric
05/2016
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
05/2016
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2015
1Liver GlycogenIBA
07/2015
1Evans Blue (Blue, Evans)FDA Link
03/2015
1Coloring Agents (Dyes)IBA
03/2015
1ElastinIBA
02/2015
1member 1 small inducible cytokine subfamily EIBA
02/2015
1Staphylococcal Protein A (Protein A)IBA
02/2015
1Adrenergic Receptors (Adrenergic Receptor)IBA
11/2014

Therapy/Procedure

8Therapeutics
11/2013 - 12/2003
2Caloric Restriction
03/2012 - 09/2011
2Denervation
11/2006 - 10/2003
1Induced Hypothermia
01/2018
1Microspheres (Microsphere)
11/2015